Vigora® (Sildenafil Citrate) is a Viagra® equivalent. It is manufactured by German Remedies Ltd (India). Like Viagra®, Vigora® is used in the treatment of Impotence.
Sildenafil Citrate 100mg
Vigora is a medicine that helps to fight erectile dysfunction. Vigora is produced by large pharmaceutical company Germanremedies. Vigora is marketed in the form of oral tablets. Each Vigora tablet contain 100mg of Sildenafil (citrate).
Our online pharmacy gives you the opportunity to buy Vigora tablets online from any country of the world. Before purchasing Vigora – Sildenafil) online you can always consult our online pharmacist and ask any questions you want.
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VIGORA PHARMACOLOGICAL ACTION
Erection is a combination of physiological and psychological processes. Sexual stimulation helps to release nitric oxide (NO) in the cavernous bodies. NO stimulates enzyme guanylate cyclase, which in turn increases the levels of cyclic guanosine monophosphate (cGMP). This physiological process provides relaxation of the smooth muscles and dilation of the arteries, responsible for good blood flow. Intensive blood supply results in stable rigidity of the penis.
Erectile dysfunction is characterized by low levels of cGMP, therefore the relaxation of smooth muscles does not occur, arteries do not dilate and blood flow is insufficient for erection. Vigora restores the natural mechanism of erection.
The active substance Sildenafil is a PDE5 inhibitor, which enhances the effect of NO, thereby increasing the level of cGMP up to normal. Thus Vigora eliminates the main cause of erectile dysfunction and provides intensive blood inflow to the penis. Because nitric oxide (NO) can only be released with sexual stimulation, then man needs some sexual stimulus after he takes Vigora.
When you take Vigora pills on empty stomach, Vigora is quickly absorbed from gastrointestinal tract. Herewith Vigora bioavailability is 40%. Pharmacokinetics of Vigora is dose-dependent. Fatty food can slow down the absorption of the drug by 30%. Maximal concentration of Sildenafil depends on individual characteristics of the body, it ranges between 30 and 120 minutes. The average time of peak concentration of the drug is 60 minutes after oral intake.
INDICATIONS FOR USE OF VIGORA
Vigora is recommended for erectile dysfunction of different origin and severity, characterized by the following symptoms:
- Partial or complete lack of erection.
- Inability to maintain erection within the whole sexual intercourse.
- Decrease in sexual desire.
- Decreased quality of orgasm.
SIDE EFFECTS OF VIGORA
Vigora has vasodilating effect, which helps to increase the blood flow to the penis. However, this stimulating effect of Vigora may cause side effects: headache, postural hypotension, tachycardia or heart failure.
Since sexual activity is a risk factor for patients with cardiovascular diseases, the usefulness of Vigora drug must be considered in each case individually.
Priapism (continuous painful erection) occurs rarely after the use of Vigora pill, yet it may arise in men with anatomic deformation of the penis.
Vigora is not recommended for combined use with Ritonavir, nitric oxide donators and nitrates. This drug interaction causes low blood pressure.
In healthy volunteers Vigora did not cause any side effects. However if men have chronic diseases, they may have some unwanted side effects sometimes. Therefore man should inform the doctor about present diseases and ask to adjust Vigora dosage.
VIGORA DOSAGE AND RECOMMENDATIONS FOR USE
The initial Vigora dose for men without chronic illnesses, is Vigora 50mg once daily.
If erection is not good enough, Vigora dose can be increased up to Vigora 100mg, taken one time a day.
With severe renal or hepatic insufficiency, it is recommended to take Vigora 25mg once daily. This is caused by low creatinine clearance of Sildenafil in patients of this group. If Vigora 25mg dosage is well digested, one can increase the dose up to 100mg per day.
Single dose of Vigora 25mg is recommended for men, who take alpha-blockers. Men of this group should take reduced doses of Vigora, because of hypotensive effect of Vigora drug.
Usually Vigora dose is taken an hour prior sexual activity in order to be able to have sex already in 60 minutes. But Vigora can be taken within interval between 30 minutes and 4 hours before sexual activity.
Vigora drug is not addictive. Therefore there is no need to increase Vigora daily dose regularly during long-term therapy of erectile dysfunction.
Men are recommended to temporarily stop taking Vigora pills, when holding antifungal or antibacterial therapy. For instance, Vigora drug should never be taken along with antifungal drugs Itraconazole and Ketoconazole, as well as with macrolide antibiotics Clarithromycin and Erythromycin.
Product Info: Vigora®
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